Neurofibromatosis type-1 and pregnancy: a review

Authors

  • Stavros Sifakis
  • Konstantinos Kalmantis Department of Obstetrics & Gynecology
  • Asimakis Karagiannopoulos Department of Obstetrics & Gynecology

Keywords:

neurofibromatosis, neurofibromatosis type-1, NF1, pregnancy.

Abstract

Introduction: Neurofibromatosis type-1 (NF1) is an autosomal dominant tumor predisposition genetic disease, with diverse expression that can affect almost any organ system. Pregnancy among patients with NF1 is remarkably stated as at high risk of complications.

Purpose: To present a short and comprehensive review of the literature concerning the relation between pregnancy and NF1.

Materials and Methods: Articles identification through electronic databases was performed by using key terms: pregnancy, neurofibromatosis, neurofibromatosis type-1.

Pregnancy issues: Most of the relevant citations are edited to announce case reports or studies based on few patients‚ samples. Since, authors in the past frequently delivered conflicting results, new retrospective studies, based on larger patient groups and matched with control groups, showed up over the last decade, to support that pregnancy in patients with NF1 is actually at high risk of complications.

Conclusions: Pregnancy in women with NF1 seems to be notably at higher risk of complications, especially hypertension/preeclampsia, IUGR, stillbirth, preterm labor, cesarean section and maternal tumor growth tendency aggravation. Despite, most authors strongly recommend close monitoring of these patients during pregnancy, a normal outcome seems to be more probable to occur.

Author Biographies

Stavros Sifakis

Mitera Maternity Hospital, Heraklion, Greece

Konstantinos Kalmantis, Department of Obstetrics & Gynecology

Alexandra Hospital, Athens, Greece

Asimakis Karagiannopoulos, Department of Obstetrics & Gynecology

Alexandra Hospital, Athens, Greece

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Published

2021-07-13